O-1783

O-1783 is a small-molecule chemical compound that is a dopamine reuptake inhibitor with an IC50 of 17 nM. It is a methylphenidate analogue of a aryltetrahydropyranyl methyl esther core chemical scaffold that is a potent transporter inhibitor that is nearly 35% biologically active than DL-threo methylphenidate.

Behind the Scenes

 * In the real world, was synthesized and characterized by Meltzer et. al in 2003 at Organix, Inc. and Harvard Medical School at Woburn, Massachusetts and Boston, Massachusetts, respectively.
 * Article writer RelentlessRecusant found out about through his personal studies in chemical biology.